Zhongze Gu
Zhongze Gu, Ph.D.
State Key Laboratory of Bioelectronics,
School of Biological Science and Medical Engineering,
Southeast University,
Sipailou 2, Nanjing, Jiangsu 210096, China
Tel: +86-25-83795635
Email: gu@seu.edu.cn


Dr. Zhongze Gu graduated from Southeast University (China) in 1989 and got his M.S. in 1992 there. He went to The University of Tokyo (Japan) in 1994 and obtained his Ph.D. in 1998. Since then, he had been working as a researcher at the Kanagawa Academy of Science and Technology. He then began a project to study the opal photonic crystals and made a lot of excellent work in this field. Since 2003, he began to work at Southeast University as a professor Cheung Kong Scholars of Biomedical Science and Medical Engineering. Now he is the dean of School of Biological Science and Medical Engineering, the director of State Key Laboratory of Bioelectronics. His researches related to bio-inspired intelligent materials, photonic crystal, biosensor and bioelectronics. He has published more than two hundred research papers in international journals and applied more than 70 related patents.


Fabrication of functional liver on a chip as drug evaluation system

Organ-on-a-chip systerm is a kind of new biomedical research methods to recapitulate organ-level structures and functions for drug evaluation and disease model. The liver is the most important detoxification organs, building physiological liver on a chip will provide a good platform for drug screening. Here we developed a microvessel liver on a chip which is effectively simulating the complex physiological microstructure and microenvironment of hepatic lobule based on cellular aggregates. This systerm contains an inverse opal porous membrane mimicing vascular endothelial barrier properties, which divides the chip into the upper chamber as bionic microvessel area and lower chamber as hepatocytes aggregates and multicellular partition co-culture area. It also contains delicate microstructures for capturing and localized culturing primary hepatocytes aggregates and maintains their functional activity such as albumin secretion and urea synthesis, and online evaluates the toxic effects of model drugs such as exposed to acetaminophen. This drug evaluation systerm should find more potential applications in biomedical research field.
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  September 15, 2017