Shoji Takeuchi
Shoji Takeuchi, Ph.D.
Professor, Director,
Center for International Research on Integrative Biomedical Systems (CIBiS),
Institute of Industrial Science (IIS),
University of Tokyo.
4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, JAPAN
TEL: +81-3-5452-6650; FAX: +81-3-5452-6649
Email: takeuchi@iis.u-tokyo.ac.jp

Biography:

Dr. Shoji Takeuchi received the B.E, M.E., and Dr. Eng. degrees in mechanical engineering from the University of Tokyo, Tokyo, Japan, in 1995, 1997, and 2000, respectively. He is currently a Professor and Director of the Center for International Research on Integrative Biomedical Systems (CIBiS), Institute of Industrial Science (IIS), University of Tokyo. He has authored more than 150 peer-reviewed publications and filed over 70 patents. He has been recognized with numerous honors including MEXT Young Scientists' Prize in 2008, the JSPS prize in 2010, and ACS Analytical Chemistry Young Innovator Awards in 2015.  His current research interests include 3D tissue fabrication, implantable devices, artificial cells/lipid bilayersystems, and biohybrid MEMS.


Abstract:

Cell fiber technology for in vitro 3D tissue fabrication

Fiber based assembly is broadly attractive in various industrial fields including clothes, optical communications, and minimal invasive operations with endoscopes. Recently our group demonstrates several types of hydrogel microfibers for continuous glucose monitoring, supra molecular assembly, and nanofiber alignments. In this talk, I propose versatile fiber-shaped cellular building units, named "cell fiber" as an alternative approach to our previous reported beads-based tissue construction.

The cell fiber was produced in a double coaxial laminar flow microfluidic device. The core stream of cells suspended in ECM sol and the shell stream of sodium alginate sol form a core-shell laminar co-flow in the device; the flow of Na-alginate sol becomes a gel at the point where it merges with the sheath stream of calcium chloride solution. As a result, a Ca-alginate shell with the cells and ECM sol in the core can be continuously generated on a meter-length scale. The three-dimensionally cultured cells in the fiber show excellent intrinsic functions. When with myocytes, endothelial, and nerve cells, they showed the contractile motion of the myocyte cell fiber, the tube formation of the endothelial cell fibers and the synaptic connections of the nerve cell fiber, respectively. By using microfluidic handling, higher-order assembly of fiber-shaped 3D cellular constructs can be performed; in particular, mechanical weaving of cell fibers with our lab-made microfluidic weaving machine provides a woven "cell fabric" composed of three different cell fibers. As the practical application, the fiber encapsulating beta-cells is used for the implantation of diabetic mice, and succeeded in normalizing the blood glucose level.
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Key Dates

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Deadline for early registration
  September 15, 2017