Wojciech Swieszkowski
Wojciech Swieszkowski, Ph.D.
Habil., WUT Professor. Biomaterials Group, Materials Design Division,
Faculty of Materials Science and Engineering,
Warsaw University of Technology (WUT),
141 Woloska Str., 02-507 Warsaw, POLAND.
phone: + 48 22 234 81 51; fax.: + 48 22 234 87 50
Email: wojciech.swieszkowski@inmat.pw.edu.pl
Website: www.bio.materials.pl

Biography:

Dr. Wojciech Swieszkowski is a professor in Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, POLAND. He is an expert in the field of biofabrication and bioprinting, biomaterials for implants and tissue engineered products, computational modeling and characterization of biomaterials. He leads BioMaterials Group (7 post doctorate and 12 PhD students, www.bio.materials.pl). He has been leader and project manager of 10 international and 15 national projects with total funding > 10M EURO. He plays a role of Faculty Coordinator of ERASMUS Program as well as the Polish-Japan PhD study in Materials Science. He has been an author of more than 100 publications, 16 book chapters and 7 patents, over 1300 citations. He was a laureate of several awards including 1st Prize of Prime Minister of Poland (2001) and Prizes from the Rector of the Warsaw University of Technology for scientific achievement (2011, 2012, 2013, 2014).


Abstract:

3D bioFABRICATION in musculoskeletal tissue engineering

3D biofabrication helps in development of highly customizable and highly organized bio-structures that, in principle, could be used for personalized tissue engineering and regeneration of different types of tissues and organs. This emerging biotechnology relies on the simultaneous deposition of cells and biomaterials to form 3D heterogeneous constructs that can mirror relevant complex biological architectures both physiologically and morphologically. Thanks to these attractive features, 3D biofabrication is rapidly becoming an interesting technique for engineering of musculoskeletal tissues.

This study shows an innovative 3D bioprinting approach, which is based on a microfluidic printing head coupled to a co-axial needle extruder for high-resolution computer-controlled 3D deposition of hydrogel fibers laden with different cells. By formulating tailored hydrogel based bioink and precisely controlling the 3D spatial organization of the extruded hydrogel fibers, the novel 3D bioprinting method has been tested for the fabrication of advanced engineered constructs for the regeneration of musculoskeletal tissues [1,2]. Depending on application, the biomimetic hydrogels were composed of modified biopolymers like gelatin, alginate, hyaluronic acid, or PEG-fibrinogen. The gels were laden with different types of cells including bone marrow-derived human mesenchymal stem cells, muscle precursor cells or chondrocytes. The obtained with high resolution (~ 100 mm), a fiber-based 3D printed constructs generated organized musculoskeletal tissues like cartilage, tendon and muscle in vitro and in vivo.

Acknowledgements: This study was partially supported by Grant No. STRATEGMED1/233224/10/NCBR/2014; Project START.
[1] Costantini M, et al. 3D bioprinting of BM-MSCs-loaded ECM biomimetic hydrogels for in vitro neocartilage formation. Biofabrication, 2016, 8 35002.
[2] Costantini M et al. Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofibers in vitro and in vivo. Biomaterials, 2017, 131 98–110.

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  September 15, 2017