Helen H. Lu
Helen H. Lu, Ph.D.
Professor of Biomedical Engineering,
Columbia University,
New York, NY 10027
Email: hl2052@columbia.edu

Biography:

Dr. Helen H. Lu received her undergraduate and graduate degrees in Bioengineering from the University of Pennsylvania, and is currently the Professor of Biomedical Engineering and the Director of the Biomaterials and Interface Tissue Engineering Laboratory at Columbia.  She also received tenure at the Columbia College of Dental Medicine, and is currently a Provost Leadership Fellow at the university.  Prof. Lu's research focuses on Orthopaedic Interface Tissue Engineering and the formation of complex tissue systems, with the goal of achieving integrative and functional repair of soft tissue injuries.  Additionally, her research group is active in the design of novel biomaterials for orthopedic and dental applications. Her research has been recognized with many awards, including the Early Faculty Career Awards in Translational Research (Phase I and Phase II) from the Wallace H. Coulter Foundation and the Young Investigator Award from the Society for Biomaterials. Dr. Lu was honored with the Presidential Early Career Award for Scientists and Engineers (PECASE) at the White House in 2010, and was elected as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) in 2011. Her group has published over ninety original research articles, invited reviews and book chapters in biomaterials and tissue engineering, and she is the inventor and co-inventor of more than a dozen patents and applications. Prof. Lu has given over 140 invited lectures at national as well as international conferences and institutions. She serves on the editorial board of leading journals of the fields, including Tissue Engineering, Journal of Biomedical Material Research A, Journal of Orthopaedic Research, Regenerative Biomaterials, Regenerative Engineering and Translational Medicine, and as Associated Editor for IEEE Transactions on Biomedical Engineering.  Prof. Lu's research is supported by the Whitaker Foundation, the Wallace H. Coulter Foundation, the Musculoskeletal Transplant Foundation, the New York State Stem Cell Initiative, the National Football League (NFL) Charities, the Department of Defense and the National Institutes of Health.


Abstract:

Scaffold Design and Fabrication for Engineering Complex Tissues

Musculoskeletal motion is orchestrated by synchronized interactions between multiple tissue types and the seamless integration of bone with soft tissues such as tendons, ligaments or cartilage. Specifically, ligaments connect bone to bone while tendons connect muscle to bone.  Moreover, many of these soft tissues transit into bone through a multi-region fibrocartilaginous interface, which serves to minimize the formation of stress concentrations while enabling load transfer between soft and hard tissues. Given their critical role in physiological motion, complexity of these functional tissue units have become a design consideration for tissue engineered orthopaedic grafts. Using the classic rotator cuff tendon-to-bone enthesis as an example and inspired by current understandings of the native interface structure-function relationship, the design and fabrication of complex scaffolds for multi-tissue integration will be discussed, with the focus on strategic biomimicry and functional tissue integration.
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Deadline for early registration
  September 15, 2017