Kaiming Ye
Kaiming Ye, PhD
Professor and Chair,
Department of Biomedical Engineering,
Watson School of Engineering & Applied Science,
Director,
Center of Biomanufacturing for Regenerative Medicine,
Binghamton University,
State University of New York (SUNY)
PO Box 6000, Binghamton, NY, 13902-6000
(O) 607-777-5887 (Assistant)
607-777-5774
Email: kye@binghamton.edu

Biography:

Dr. Kaiming Ye is Professor and Department Chair of Biomedical Engineering and Director of Center of Biomanufacturing for Regenerative Medicine at Binghamton University (BU), State University of New York (SUNY). He is one of the top most distinguished and accomplished leaders in the field of Medical and Biological Engineering. He is fellow of AIMBE and senior member of IEEE. His scholarly contributions to the field include the development of the concept of advanced biomanufacturing and his leadership role in promoting and growing the field. He organized and co-organized more than 10 conferences and workshops as well as two WTEC studies including Global Assessment of Stem Cell Science and Engineering and Global Assessment of Advanced Biomanufacturing. He is well-known for his work in bioprinting and human pancreatic organoid development from stem cells. He has invented fluorescent nanosensors for continuous glucose monitoring. His work in advanced biomanufacturing was featured as a cover story of ASEE PRISM. His work in glucose sensors was featured in the Pittsburgh Post-Gazette. He has delivered keynote/plenary speech in numerous international and national conferences. He serves as Associate Editor, and member of Editorial Boards of 13 journals. He is also a highly accomplished administrator and has contributed significantly to national policy-make in science and engineering. During his tenure at NSF, he directed a biomedical engineering program, making funding decisions and implementing post-award management. He was a member of a number of interagency working groups, including the Interagency Workgroup for Neuroscience under the Office of Science and Technology Policy (OSTP), Interagency Modeling and Analysis Workgroup, and Multiagency Tissue Engineering and Regenerative Medicine Workgroup. Finally, he is a highly accomplished educator in biomedical engineering. As chair of Biomedical Engineering Department at BU, he led the growth of the Department.


Abstract:

Development of Pancreatic Islet Organoids from Human Pluripotent Stem Cells

Ability of biofabricating highly organized multicellular tissue constructs enables the production of individualized organs for patient-tailored organ transplantation or individualized tissues for cell-based therapy. These lab-produced high order tissues and organs can serve as disease models for pathophysiological study and drug screening. We have developed an innovative tissue assembly technology for biofabricating islet organoids from human pluripotent stem cells (HPSCs). The organoids formed consisted of α, β, d, and pancreatic polypeptide (PP) cells and exhibited tissue architectres similar to adult islets. A high level expression of C-peptide upon glucose challenge confirmed the de novo endogenous insulin production from these organoids. The use of tissue inspired biomaterials suggests the feasibility of biofabricating large quantity of islets for diabetes treatment.
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Deadline for early registration
  September 15, 2017