Yong Chen
Yong Chen, Ph.D.
Ecole Normale Supérieure, CNRS-ENS-UPMC UMR 8640, 75005 Paris
Email: yong.chen@ens.fr

Biography:

Yong Chen received his Ph.D. in Condensed Matter Physics from the University of Montpellier in 1986. After three years at the Scuola Normale Superiorie di Pisa and Peking University, he became a CNRS researcher in 1990 and then moved to the Ecole Normale Supérieure of Paris in 2003. He is now a 1st class CNRS Research Director and a Changjiang scholar of Peking University. He is author or co-author of more than 400 papers in scientific journals of different fields.


Abstract:

Cell patch method

To overcome the difficulty of in-vitro culture of human pluripotent stem cells (hPSCs) which is essential for advanced disease modeling, drug screening and regenerative medicine, we developed a cell patch method based on in-vivo extracellular matrix (ECM) mimicking. Unlike conventional approaches using culture dish or plastic substrates, we used ECM proteins to create a two dimensional (2D) network made of a monolayer of crosslinked nanofibers on a honeycomb micro-frame (patch). This patch device can be used for suspension culture, plug-and-play monitoring and microfluidic integration or organs-on-a-chip systems. When cells are cultured on the patch, they will have a minimal contact with exogenous materials and a maximal exposure to the culture medium. When hPSCs are cultured on the patch, one can easily control their shape of the cell colonies and efficiently differentiate them into different types of adult cells. We show that the hPSC derived cardiomyocytes (Tang et al, Nanoscale 2016) or motor neurons (Tang el al, J. Mat. Chem. 2016) in such a way are highly functional for both in-vitro and in-vivo assays. In this talk, we will discuss some related issues of this method toward large scale applications.



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Key Dates

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Deadline for early registration
  September 15, 2017