Jason A. Burdick
Jason A. Burdick, Ph.D.
Professor
Department of BioengineeringUniversity of Pennsylvania
Office:  102 Hayden Hall
Mail: 240 Skirkanich Hall
Philadelphia, PA  19104
Phone:  215-898-8537
Fax:  215-573-2071
www.seas.upenn.edu/~burdick2

Biography:

Jason A. Burdick, PhD is a Professor of Bioengineering at the University of Pennsylvania.  Dr. Burdick's research involves the development of hydrogels for various biological applications and his laboratory is specifically interested in understanding and controlling polymers on a molecular level to control overall macroscopic properties. The applications of his research range from controlling stem cell differentiation through material cues to fabricating scaffolding for regenerative medicine and tissue repair. Jason currently has over 200 peer-reviewed publications and has been awarded a K22 Scholar Development and Career Transition Award through the National Institutes of Health, an Early Career Award through the Coulter Foundation, a National Science Foundation CAREER award, a Packard Fellowship in Science and Engineering, and an American Heart Association Established Investigator Award.  He is on the editorial boards of Tissue Engineering, Biomacromolecules, Biofabrication, and Journal of Biomedical Materials Research A, and is an Associate Editor for ACS Biomaterials Science & Engineering.


Abstract:

Extrusion-based 3D Printing of Biodegradable Polymers

Our laboratory is interested in developing new biomaterials for 3D printing, as well as new printing processes to expand the utility of 3D printing in biomedical applications. 3D printing techniques possess great potential to fabricate complex and multiscale structures as in vitro models or for tissue engineering applications. Such strategies may use open-source technologies that are economical and permit diverse printing approaches, such as  extrusion-based printing. In this case, the properties of the biomaterial ink are important and involve the transition of flowing ink into a solid material. We have pursued standard printing approach using a range of material systems, including shear-thinning and stabilizing hydrogels and photocrosslinkable and biodegradable elastomers (e.g., poly(glycerol sebacate)).

Beyond the direct extrusion of inks onto a surface, we have developed a technique that involves the printing of a shear-thinning and self-healing hydrogel ink into another support hydrogel in 3D space [1].  Shear forces disrupt the hydrogel structure for extrusion and also to receive the extruded material, with resolutions dependent on needle diameter, printing speed, and extrusion rate. More recently, we developed an approach for the direct 3D printing of photocrosslinkable hydrogels, including those that are non-viscous [2].  Here, we controlled where light exposure occurs during the printing process (i.e., during the extrusion and before leaving the needle).  This has allowed us to print a range of non-viscous photocrosslinkable hydrogels with high cell viability and with heterogeneous structures.

[1] C.B. Highley, C.B. Rodell, J.A. Burdick, Direct 3D Printing of Shear-thinning Hydrogels into Self-healing Hydrogels, Advanced Materials, 27:5075-5079, 2015.
[2] L. Ouyang, C.B. Highley, W. Sun, J.A. Burdick, A Generalizable Strategy for the 3D Printing of Hydrogels from Non-viscous Photocrosslinkable Inks, Advanced Materials, 29:1604983, 2017.

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