Dong Sung Kim
Dong Sung Kim, Ph.D.
Department of Mechanical Engineering,
Pohang University of Science and Technology (POSTECH), Korea
Email: smkds@postech.ac.kr

Biography:

Dr. Dong Sung Kim is an Associate Professor in the Department of Mechanical Engineering at POSTECH, Korea. He received all his B.S., M.S., and Ph.D. (Advisor: the late Prof. Tai Hun Kwon) from POSTECH in 1999, 2001, and 2005, respectively, developing disposable plastic labs-on-a-chip for blood typing. After one year of post-doc in POSTECH, he joined the School of Mechanical Engineering at Chung-Ang University in Korea as a faculty member. After 4 years in Chung-Ang University as a Full-time Lecturer and an Assistant Professor, he came back to POSTECH as a faculty member in 2010. His current research is basically focused on the development of polymer micro/nanofabrication and its utilization in bio-engineering and energy harvesting. He intensively studied on the biomedical fields with micro/nano polymer processing, such as polystyrene micro/nanoengineered cell culture platforms, electrospun nanofiber structures, multifunctional stimuli-responsive structures, and disposable lab on a chip. Prof. Kim has published over 80 peer-reviewed journal papers, registered 27 patents including 3 US patents, and served on the editorial/advisory board of several international journals and symposia.


Abstract

Electrolyte-assisted electrospinning to fabricate a free-standing, spatially controlled nanofiber membrane for guided tissue formation

A physical microenvironment of cells, such as nanotopography of extracellular matrix (ECM) is one of important factors to regulate cell fate and functions. Many previous works have investigated the cell behaviors including orientation, migration, proliferation, and differentiation and tried to guide tissue formation by nanofiber topographies. Here, we suggest a free-standing, spatially controlled nanofiber membrane which mimics the physical topography of the ECM for guided tissue formation: the reconstruction of a 3D multi-layered blood vessel/tissue interface composed of an endothelial monolayer, a basement membrane and perivascular components.

To construct a free-standing, spatially patterned or aligned nanofiber membrane, we developed an electrolyte-assisted electrospinning process, named ELES, which utilized an electrolyte solution as a temporal collector instead of the metal. Conventional electrospinning produced a nanofiber membrane that is strongly adhered to the metal collector, which in turn requires further processing to integrate it with a microfluidic channel. In contrast, the ELES enables simultaneous fabrication and integration of the free-standing, patterned or aligned nanofiber membrane on the microfluidic channel. By utilizing the ELES, we could fabricate a free-standing nanofiber membrane with the novel properties of anisotropic topography, ultra-thin thickness (~ 1 mm), high porosity, and semi-transparency, which served as an ideal platform to mimic in vivo 3D blood vessel/tissue interface. On the nanofiber membrane, we could develop a 3D multi-layered blood vessel/tissue model, which allowed to scrutinize multicellular dynamics like the T-cell adhesion cascade, which is found in in vivo blood vessel.
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Deadline for early registration
  September 15, 2017